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Arch Facial Plast Surg. 2007;9(5):370-371.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Archives of Surgery

Reduction of the Incidence of Amputation in Frostbite Injury With Thrombolytic Therapy

Hypothesis: Thrombolytic therapy will decrease the incidence of amputation when administered within 24 hours of exposure.

Design: Single institution retrospective review of clinical outcomes and resource use.

Setting: Burn unit of a tertiary academic referral center.

Patients: From 2001 to 2006, patients with severe frostbite admitted within 48 hours of injury underwent digital angiography and treatment with intra-arterial tissue plasminogen activator (tPA) if abnormal perfusion was demonstrated. These patients were compared with those treated from 1995 to 2006 who did not receive tPA.

Interventions: Tissue plasminogen activator vs traditional management of frostbite injury.

Main Outcome Measures: Number and type of surgery were recorded, along with amputations of digits (fingers or toes) and more proximal (ray, transmetatarsal, or below-knee) amputations. Resource utilization including length of stay, total costs, cost per involved digit, and cost per saved digit were analyzed.

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Archives of Surgery

Archives of Surgery

Archives of Internal Medicine