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Hyaluronidase and Restylane
Charles N. S. Soparkar, MD, PhD;
James R. Patrinely, MD;
Bentley C. Skibell, MD;
Robert N. Tower, MD
Arch Facial Plast Surg. 2007;9(4):299-300.
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We congratulate Vartanian et al on their investigation of the effects of hyaluronidase on Restylane (Q-Med AB, Uppsala, Sweden), a nonanimal, stabilized hyaluronic acid in test subjects' arms.1 This excellent work has received the wide attention it deserves, a tribute to Archives’ broad readership. A number of misconceptions arising from this study, however, have made their way into common clinical practice and are now even secondarily cited.2
To support the following comments, we direct readers to 2 articles predating the work of Vartanian et al in which nonpreserved hyaluronidase was documented to effectively diminish Restylane in the face.3-4
Misconception 1
Hyaluronidase Causes an Inflammatory Reaction in 25% of Patients
This belief is based on an observation that 3 of 12 patients suffered "localized allergic reactions following hyaluronidase injection,"1(p235) 1 patient "within 30 minutes"1(p236) and the other 2 "within hours."1(p233) As previously reported,4 . . . [Full Text of this Article]
Misconception 2
No More Than 5 to 10 U of Hyaluronidase Should Be Used at a Time
Misconception 3
Hyaluronidase Takes 1 to 2 Weeks to Be Maximally Effective on Restylane
AUTHOR INFORMATION
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