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Arch Facial Plast Surg. 2009;11(5):354-355.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Archives of Dermatology

Molecular Effects of Photodynamic Therapy for Photoaging

Objective: To quantitatively examine the epidermal and dermal cellular and molecular changes that occur after photodynamic therapy of photodamaged human skin.

Design: Serial in vivo biochemical and immunohistochemical analyses after photodynamic therapy using topical 5-aminolevulinic acid (5-ALA) and pulsed-dye laser treatment.

Setting: Academic referral center, Department of Dermatology, University of Michigan, Ann Arbor.

Patients: A volunteer sample of 25 adults, 54 to 83 years old, with clinically apparent photodamage of the forearm skin.

Interventions: Three-hour application of 5-ALA followed by pulsed-dye laser therapy using non–purpura-inducing settings to focal areas of photodamaged forearms and serial biopsy specimens taken at baseline and various times after treatment.

Main Outcome Measures: Immunohistochemical analysis was used to assess levels of markers of epidermal proliferation (Ki67), epidermal injury (cytokeratin 16), and photodamage (p53), as well as various markers of dermal collagen production (including prolyl 4-hydroxylase and heat shock protein . . . [Full Text of this Article]