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Sam P. Most, MD

Arch Facial Plast Surg. 2007;9(5):340-343.

Objective  To examine the efficacy of 2 over-the-counter cosmeceutical creams in reducing facial rhytids—Freeze 24/7 Anti-Wrinkle Cream (Freeze 24/7 International LLC, New York, New York) and LiftFusion Micro-Injected M-Tox Transdermal Face Lift (Fusionbeauty, Inc, Boca Raton, Florida)—against placebo (Nutraderm Therapeutic Lotion; Healthpoint, Inc, San Antonio, Texas).

Methods  A prospective, blinded clinical trial was performed on 42 subjects, comparing 2 cosmeceutical creams that each represent a class of purported rapid rhytid reduction formulas with placebo. Independent analysis by 2 facial plastic surgeons was performed as well as completion of self-assessment questionnaires by the participants.

Results  No complications occurred. Self-evaluation of cream effectiveness was no different for test creams compared with placebo. Neither cream produced substantial reduction of rhytids when examined critically by 2 independent facial plastic surgeons. Stratification by Glogau (photoaging) class did not reveal increased effectiveness based on rhytid severity.

Conclusion  Two typical over-the-counter rhytid reduction products are ineffective at substantially reducing facial rhytids.

Author Affiliation: Division of Facial Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, California.