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Stephen Bosniak, MD; Marian Cantisano-Zilkha, MD; Ioannis P. Glavas, MD

Arch Facial Plast Surg. 2004;6:379-383.

Objective  To evaluate the effectiveness of nonanimal stabilized hyaluronic acid as an injectable filling agent.

Design  Nonrandomized, retrospective, interventional case series.

Results  A total of 1446 consecutive patients (1029 women and 417 men) underwent intradermal injection of commercially available nonanimal stabilized hyaluronic acid (2242 treatments) for the enhancement of lip volume and contour and the reduction of visible facial rhytids. Almost 61% of all patients remained satisfied with their results after 9 months. The effect was longest in the glabellar and nasolabial fold areas. Minimal transient sequelae were noted.

Conclusions  Nonanimal stabilized hyaluronic acid is an effective and safe facial soft tissue expander. Its duration varies with each facial area treated.

Author Affiliations: Manhattan Eye, Ear, and Throat Hospital, New York, NY (Drs Bosniak and Glavas), and Center for Clinical Studies, Oftalmoclinica Botafogo, Edificio Colegio Brasileiro De Cirurgioes,Rio de Janeiro, Brazil (Dr Cantisano-Zilkha).

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