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The Effect of Subcutaneously Administered Low-Molecular-Weight Heparin on Microarterial Thrombosis in the Rat
Tessa A. Hadlock, MD;
Jennifer Kim, MD;
Daniel G. Deschler, MD
Arch Facial Plast Surg. 2003;5:36-39.
Objective To examine the effect of administration of a low-molecular-weight heparin derivative, enoxaparin, on the rate of arterial thrombosis in a rat model.
Study Design Prospective, randomized, blinded study.
Methods A standard microarterial anastomosis tuck injury was created in both femoral arteries of 25 Long Evans retired breeder rats. Thirteen animals received a subcutaneous injection of 50 IU/kg of enoxaparin 2 hours before the procedure, while 12 control animals received vehicle (isotonic sodium chloride solution) alone. Sites of injury/repair were assessed 2 hours after the procedure for anastomotic patency or thrombosis.
Results Six (23%) of 26 vessels in the drug-treated group developed an arterial thrombosis at the site of repair, while 6 (25%) of 24 vessels in the control group developed thrombosis. There was no statistically significant difference at the 95% confidence limit between the 2 groups based on a comparison-of-proportions test.
Conclusion The preoperative subcutaneous administration of 50 IU/kg of enoxaparin did not alter the rate of arterial thrombosis following the creation of a thrombogenic tuck injury/repair of the rat femoral artery.
From the Departments of Otolaryngology–Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, and Otology and Laryngology, Harvard Medical School, Boston Mass.
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