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Tissue Response to Expanded Polytetrafluoroethylene and Silicone Implants in a Rabbit Model
Rami K. Batniji, MD;
Joseph L. Hutchison, MD;
Ravi Dahiya, MD;
Samuel L. Lam, MD;
Edwin F. Williams III, MD
Arch Facial Plast Surg. 2002;4:111-113.
Background Expanded polytetrafluoroethylene (ePTFE) and silicone are safe and relatively
biocompatible materials.
Objective To compare, using multiple histologic parameters, the tissue response
to a standard silicone soft tissue implant with the response to a modified
ePTFE implant. The modified form of ePTFE is reinforced with fluorinated ethylene
propylene (FEPRePTFE), which provides increased pliability and material integrity.
Methods The implants were placed into a subperiosteal pocket over the skull
of adult New Zealand white rabbits. At 7, 30, and 90 days after implantation,
en bloc tissue specimens, including skin, implants, surrounding soft tissue,
and underlying bone were harvested for gross and histologic evaluation.
Outcome Measures The tissue response to the implants was assessed with respect to the
number of foreign body giant cells present, the thickness of the fibrous capsule,
and the general inflammatory response (n = 6 for each implant at each evaluation
period).
Results There were no cases of rejection, extrusion, or infection. The silicone
implants elicited a significantly thicker capsule and less neovascularization
(P<.05).
Conclusion The FEPRePTFE demonstrated a favorable tissue response when compared
with silicone, particularly in regard to capsule thickness and vascular ingrowth.
From the Division of Otolaryngology, Albany Medical Center, Albany,
NY.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Long-term Evaluation of Porous PEGT/PBT Implants for Soft Tissue Augmentation
Lamme et al.
J Biomater Appl 2008;22:309-335.
ABSTRACT
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