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Enhancement of Auricular Composite Graft Survival With Hyperbaric Oxygen Therapy
Gregory Renner, MD;
Stacie D. McClane, MD;
Elizabeth Early, MD;
Patricia Bell, MD;
Bharat Shaw, MD
Arch Facial Plast Surg. 2002;4:102-104.
Objective To continue investigation regarding the efficacy of hyperbaric oxygen
(HBO) therapy in improving survival of reattached auricular composite grafts.
Design A prospective, randomized, double-blind study using 20 New Zealand albino
rabbits randomized to a treatment or control group. The treatment group received
30 HBO treatments over 19 days following amputation and reattachment of composite
auricular grafts. The control group received standard care. Ears were examined
grossly and microscopically on postoperative day 21 to determine the percentage
of graft survival.
Results The mean percentage of graft survival for the 2 separate grafts (a larger
1.5 x 4.0-cm and a smaller 1.0 x 3.0-cm graft) in the treatment
group was 26.5% and 27.9%, respectively. The mean percentage of graft survival
for the larger and smaller graft in the control group was 9.7% and 14.0%,
respectively. An analysis of variance test was used to evaluate this difference,
which was found to be statistically significant (P
= .001).
Conclusions This study represents a continued investigation following a pilot study,
which suggested some enhancement of composite graft survival with the use
of HBO therapy in the rabbit ear. Both experiments have demonstrated a slight
survival benefit using HBO therapy in auricular composite grafts in the rabbit
model.
From the Division of Otolaryngology–Head and Neck Surgery, University
of Missouri, Columbia.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Use of hyperbaric oxygen to enhance auricular composite graft survival in the rabbit model.
Lewis et al.
Arch Facial Plast Surg 2006;8:310-313.
ABSTRACT
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Hyperbaric oxygen: its uses, mechanisms of action and outcomes
Gill and Bell
QJM 2004;97:385-395.
FULL TEXT
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