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Acellular Dermis for Facial Soft Tissue Augmentation
Preliminary Report
Peter D. Costantino, MD;
Satish Govindaraj, MD;
David H. Hiltzik, BA;
Daniel Buchbinder, DMD, MD;
Mark L. Urken, MD
Arch Facial Plast Surg. 2001;3:38-43.
Objective To evaluate the efficacy of acellular dermis as a viable alternative
for soft tissue augmentation in facial reconstruction.
Design A prospective, nonrandomized observational study consisting of 10 patients
who underwent soft tissue augmentation with acellular dermis.
Setting A tertiary care university medical center in an urban setting.
Patients Ten patients who had undergone soft tissue augmentation using acellular
dermis participated in this study. Postimplantation follow-up was 17 to 36
months.
Intervention The amount and location for placement of the acellular dermis was left
to the discretion of the surgeon. All implants were placed in the subdermal
tissues.
Main Outcome Measures The adequacy of acellular dermis for soft tissue augmentation was assessed
by subjective evaluation of implant volume persistence, postoperative complications,
and the restoration of normal contour.
Results Of 10 patients who underwent implantation, 9 had no complications and
1 had a recurrent sterile abscess or mucocele at the implantation site. A
22-month postimplantation tissue sampling of acellular dermis in a patient
with recurrent tumor revealed approximately 80% to 85% volume persistence.
Conclusion Preliminary experience with acellular dermis indicates that it shows
promise in soft tissue augmentation.
From the Departments of Otolaryngology (Drs Costantino, Govindaraj,
and Urken and Mr Hiltzik) and Oral and Maxillofacial Surgery (Drs Costantino
and Buchbinder), The Mount Sinai Medical Center, New York, NY. Dr Costantino
is a consultant to LifeCell Corporation, The Woodlands, Tex, and Stryker Leibinger
Inc, Kalamazoo, Mich, and receives research funding from these companies as
well. None of the other authors have a financial interest in either of these
companies.
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