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Paul Sabini, MD; Anthony P. Sclafani, MD; Thomas Romo III, MD; Steven A. McCormick, MD; Rubina Cocker, MD

Arch Facial Plast Surg. 2000;2:27-33.

Objective  To investigate the effect of direct application of biologic materials normally present in wounds (basic fibroblast growth factor [bFGF] and autologous blood clot [ABC]) to accelerate the bony and soft tissue ingrowth into porous high-density polyethylene implants.

Methods  We conducted a prospective, blinded animal histological study. Disks made of porous high-density polyethylene impregnated with bFGF or ABC were implanted into adult Sprague-Dawley rats in both subcutaneous and subperiosteal locations. Animals were killed and implants were harvested at 2, 4, and 10 weeks postimplantation and examined histologically for fibroblast invasion, collagen deposition, and inflammatory reaction.The results were compared with control (untreated) implants.

Results  As a group, the histological results showed significantly more fibroblasts within the ABC-treated implants than control implants or bFGF-treated implants. This difference in the number of fibroblasts between ABC-treated implants and bFGF-treated and control implants was also statistically significant 2 weeks after implantation.

Conclusions  At the concentration of bFGF of 1 µg/10 µL, no acceleration of tissue ingrowth into porous high-density polyethylene implants was noted. However, when porous high-density polyethylene implants were treated with ABC, the implants were invaded to a greater degree by soft tissue, particularly in the early postoperative period (first 2 weeks). Bioactive substances associated with the coagulation and platelet cascades present in the ABC may be responsible for this accelerated incorporation of the porous implant and may have clinical implications.

From the Department of Otolaryngology–Head and Neck Surgery (Drs Sabini, Sclafani, and Romo), the Division of Facial Plastic and Reconstructive Surgery (Drs Sclafani and Romo), and the Department of Pathology (Drs McCormick and Cocker), The New York Eye and Ear Infirmary, New York; and the Department of Otolaryngology–Head and Neck Surgery, New York Medical College, Valhalla (Drs Sclafani and Romo).

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