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Efficacy of Octyl-2-Cyanoacrylate Tissue Glue in Blepharoplasty
A Prospective Controlled Study of Wound-Healing Characteristics
David Greene, MD;
R. James Koch, MD;
Richard L. Goode, MD
Arch Facial Plast Surg. 1999;1:292-296.
Objective To compare the surgical efficacy and wound-healing characteristics of the tissue adhesive octyl-2-cyanoacrylate (approved by the Food and Drug Administration) with traditional suture closure in upper blepharoplasty.
Methods Prospective, randomized, blinded study comparing cosmetic and functional outcome and time efficiency. Twenty subjects underwent upper eyelid blepharoplasty. Each patient had a control side and an experimental side determined randomly. One eyelid incision was closed with octyl-2-cyanoacrylate (Dermabond; Ethicon Inc, Somerville, NJ) tissue glue, and the other with 6.0 suture (polypropylene or fast-absorbing gut). Comparisons were performed for the time for closure by each method, wound healing, and patient satisfaction. Macrophotographs of the wounds at 1, 2, and 4 weeks after surgery were graded by 5 observers blinded to the closure method, using a 10-point scale and a modified Hollander wound evaluation scale.
Results No statistically significant difference was found between the quality of octyl-2-cyanoacrylate closure and suture closure at 1 month. There were no differences in wound complications, duration of healing, inflammation, or final incision appearance. By 2 weeks, the sides were indistinguishable in 15 (75%) of the patients. Time for closure averaged 7 minutes with suture and 8 minutes with glue.
Conclusions Octyl-2-cyanoacrylate glue is an excellent alternative to suture closure, producing equivalent quality of closure at all time points and no difference in appearance. This adhesive was sufficient to withstand the forces of closure in upper eyelid blepharoplasty without dehiscence in the absence of sutures.
From the Division of Otolaryngology–Head and Neck Surgery, Facial Plastic and Reconstructive Surgery, Stanford University Medical Center, and the Palo Alto Veteran's Affairs Health Care System, Palo Alto, Calif (Drs Greene, Koch, and Goode); and the Department of Otolaryngology–Head and Neck Surgery, Cleveland Clinic Florida, Naples (Dr Greene). The authors have no financial interest or grant support from Ethicon Inc.
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